Koh, Minseob  사진
Koh, Minseob
Position or Degree
Assistant Professor
Tell Number
(82-51) 510-2278 (실험실:)
Chemical Biology (Bioimaging, Bispecific small molecule, Small molecule switch, Directed evolution, Protein engineering, Genetic code expansion)



Ph.D., Department of Chemistry, Seoul National University (Advisor: Prof. Seung Bum Park, 2007/3-2013/8)

B.S., Department of Chemistry, Seoul National University (2003/3-2007/2)


Academic Career


Postdoctoral Associate, Scripps Research, San Diego, USA (Advisor: Prof. Peter G. Schultz, 2014/7-2020/7)

Postdoctoral Fellow, Bio-MAX/N-BIO, Seoul, South Korea (Advisor: Prof. Seung Bum Park, 2013/12-2014/6)


Research Interests


1. Small Molecule Tools

  -PROTAC (Proteolysis targeting chimera)

  -Fluorescent small molecules

  -Chemical proteomics


2. Synthetic Biology

  -Genetic encoding of non-natural synthetic amino acid

  -Engineering bacterial gene expression system


3. Protein Engineering

  -Fluorescent protein engineering


  -Directed evolution of nanobody


Selected Publication


1. Zambaldo, C.+, Koh, M.+, Nasertorabi, F.+, Han, G. W., Chatterjee, A., Stevens, R. C. & Schultz, P. G., "An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli" Bioorg. Med. Chem. 28 (20), in press (2020). (+ equal contribution)


2. Koh, M., Yao, A., Gleason, P. R., Mills, J. H. & Schultz, P. G., "A general strategy for engineering noncanonical amino acid dependent bacterial growth" J. Am. Chem. Soc. 141 (41), 16213-16216 (2019).


3. Koh, M., Cho, H.-Y., Yu, C., Choi, S., Lee, K.-B. & Schultz, P. G., "Site-specific incorporation of a dithiolane containing amino acid into proteins", Bioconjug. Chem. 30 (8), 2102-2105 (2019).


4. Koh, M., Nasertorabi, F., Han, G. W., Stevens, R. C. & Schultz, P. G., "Generation of an orthogonal protein-protein interface with a noncanonical amino acid", J. Am. Chem. Soc. 139 (16), 5728-5731 (2017).


5. Koh, M., Park, J., Koo, J. Y., Lim, D., Cha, M. Y., Jo, A., Choi, J. H. & Park, S. B. "Phenotypic screening to identify small-molecule enhancers for glucose uptake: target identification and rational optimization of their efficacy", Angew. Chem. Int. Ed. 53 (20), 5102-5106 (2014).


6. Park, J.+, Koh, M.+, & Park, S.B. "From noncovalent to covalent bonds: a paradigm shift in target protein identification", Mol. Biosyst. 9, 544-550 (2013). (+ equal contribution)


7. Koh, M., Park, J., An, H. & Park, S. B. "Ratiometric analysis of zidovudine (ZDV) incorporation by reverse transcriptases or polymerases via bio-orthogonal click chemistry", Chem. Commun. (Camb.) 47, 7614-7616 (2011).




1. Park, S. B., Koh, M., & Koo, J. Y. "Novel compound having isoxazole core and pharmaceutical composition for diabetes containing the same molecular skeletons", Korean Patent No. 10-1727634-0000 (2017).


2. Park, S. B., Kim, E., Koh, M., & Ryu, J. "Emissive fluorescent compounds, synthetic method and uses thereof", Korean Patent No. 10-0954561-0000 (2010).